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Semin Thromb Hemost 2012; 38(05): 524-529
DOI: 10.1055/s-0032-1306434
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Venous and Arterial Thrombosis Associated with HIV Infection

Francesco Dentali
1   Department of Clinical and Experimental Medicine, University of Insubria, Varese, Italy
,
Eleonora Nicolini
1   Department of Clinical and Experimental Medicine, University of Insubria, Varese, Italy
,
Walter Ageno
1   Department of Clinical and Experimental Medicine, University of Insubria, Varese, Italy
› Author Affiliations
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Publication History

Publication Date:
07 March 2012 (online)

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Abstract

The advent of highly active antiretroviral therapy (HAART) and the appropriate use of prophylactic strategies to prevent opportunistic infections have drastically decreased human immunodeficiency virus (HIV) infection-related mortality. However, there is growing evidence that metabolic abnormalities associated with HIV infection and with its treatment may lead to an increased risk of cardiovascular (CV) events. Several studies showed an increased risk of symptomatic and subclinical CV events in these patients. On the other hand, the association with venous thromboembolic events is less compelling. This increased risk is possibly explained by the coexistence in this population of different risk factors determined by the HIV infection per se, by the higher prevalence of traditional CV risk factors such as obesity, smoking, hypertension, hyperlipidemia, and glucose intolerance, as compared with the general population, and by the effects of HAART. Thus, systematic identification and aggressive treatment of traditional risk factors seem to be necessary to prevent the development of cardiovascular disease in this population.

Keywords

human immunodeficiency virus - acquired immunodeficiency syndrome - venous thrombosis - arterial thrombosis